Wednesday's detailed programme below 

Sunday 9, July | Monday 10, July | Tuesday 11, July | Wednesday 12, July | Thursday 13, July


Wednesday 12, July
09.00 10.30  IS6: Biostatistics for High Dimensional Data  OC31: Design and analysis of clinical trials 4  OC32: Multistate survival analysis and dynamic prediction 2  OC33: Heterogeneity in biomedical studies and meta-analysis  OC34: Statistical challenges of EHR (eHealth Records) analysis  PC6: Bayesian methods and joint modelling
10.30 11.00 Coffee break     
11.00 12.00 Keynote Speaker: Francesca Dominici, Harvard University, USA
Model Uncertainty and Covariate Selection in Causal Inference      
12.00 13.00 ISCB Annual General Meeting
13.00 13.30
13.30 14.30 Lunch break
14.30 16.00  IS7: Bayesian Methods in Clinical Research  OC35: Complex survival data 2  OC36: Statistical methods for precision
medicine 2

 OC37: Design and analysis of clinical

trials 5

 OC38: Statistical methods in

epidemiology 3

 PC7: Observational studies
16.00 16.30 Coffee break     
16.30 18.00  IS8: Clinical Trial Simulations: the When, Where and What  OC39: Bayesian methods in clinical research 5  OC40: Joint modelling in practice 3

 OC41: Topics in biostatistics 2


 OC42: Survival

analysis 4

 PC8: Biomedical studies 2
18.00 18.30  ISCB39 Presentation     
20.00   Conference Dinner at Hotel Pazo Los Escudos (Beach of Alcabre)





 IS6: Biostatistics for High Dimensional Data - Room: Auditorio

    Chair: Jeanine Houwing-Duistermaat

Organised by Jeanine Houwing-Duistermaat, University of Leeds, United Kingdom



IS6-1 Wessel van Wieringen, Vrije Universiteit Amsterdam, The Netherlands - Network models from time-course omics data

IS6-2 Hae Won Uh, Leiden University Medical Center, The Netherlands - Latent Variable Modelling for Multiple Omics Data

IS6-3 John Whittaker, Glaxo Smith Kline Pharmaceuticals, United Kingdom - Genomics and Drug Discovery 



 OC31: Design and analysis of clinical trials 4 - Room: Sala Mar 2

    Chair: Frank Bretz
    OC31-1 (09.00-09.18) Corine Baayen - Sequential trials in the context of competing risks – a case study
    OC31-2 (09.19-09.36) Kevin Kunzmann - Test-compatible inference for adaptive two-stage single-arm designs with binary endpoint
    OC31-3 (09.37-09.54) Meinhard Kieser - Optimal planning of phase II/III programs for clinical trials with multiple endpoints
    OC31-4 (09.55-10.12) Ayon Mukherjee - Covariate-adjusted response-adaptive designs in clinical trials where the survival responses of patients follow a semi-parametric model
    OC31-5 (10.13-10.30) Matteo Quartagno - A new design for trials for finding optimal treatment duration

 OC32: Multistate survival analysis and dynamic prediction 2 - Room: Sala Terra 2

    Chair: Klaus Langohr
    OC32-1 (09.00-09.18) Krithika Suresh [StCA winner] - Comparison of joint modeling and landmarking for dynamic prediction under an illness-death model
    OC32-2 (09.19-09.36) Ulrich Beyer - Predicting treatment outcome using intermediate state information based on a multistate landmark model including pre-landmark co-variables
    OC32-3 (09.37-09.54) Maja Katharina Von Cube - A dynamic prediction approach to analyse the population-attributable fraction of ventilator associated pneumonia
    OC32-4 (09.55-10.12) Leyla Azarang - Multi-state net survival model
    OC32-5 (10.13-10.30) Brice Ozenne - Assessing treatment effects on registry data in presence of competing risks

 OC33: Heterogeneity in biomedical studies and meta-analysis - Room: Sala Terra 4

    Chair: Jarek Harezlak
    OC33-1 (09.00-09.18) Danielle Burke - Guidance for deriving and presenting percentage study weights in meta-analysis of test accuracy studies
    OC33-2 (09.19-09.36) Samprit Banerjee - A semi-parametric approach for meta-analysis of survival curves from orthopedic registries
    OC33-3 (09.37-09.54) David Phillippo - Population-adjusted treatment comparisons: estimates based on matching-adjusted indirect comparison and simulated treatment comparison
    OC33-4 (09.55-10.12) Fotios Siannis - Longitudinal meta-analysis of percentile ratios for survival data
    OC33-5 (10.13-10.30) Valentijn De Jong - Individual patient data meta-analysis of time-to-event data: a review of the methodology

 OC34: Statistical challenges of EHR (eHealth Records) analysis - Room: Sala Mar 4

    Chair: María Durbán
    OC34-1 (09.00-09.18) Clemence Leyrat - How should missing time-varying confounders be handled to estimate marginal effects from electronic health records?
    OC34-2 (09.19-09.36) Olympia Papachristofi - The role of electronic health records in the design of trials of complex interventions: a view from surgery
    OC34-3 (09.37-09.54) Lauren Rodgers - A quasi-experimental approach to account for unmeasured confounders in the assessment of side effects using observational data
    OC34-4 (09.55-10.12) Kristi Krebs - Genetic variation in the Estonian population: a pharmacogenomic study of adverse drug reactions using electronic health records
    OC34-5 (10.13-10.30) David Cheng [StCA winner] - Efficient and robust semi-supervised estimation of treatment effects in electronic medical records data

 PC6: Bayesian methods and joint modelling - Room: Hall

    Chair: Carmen Armero
    Click here to see the posters list

 Coffee break - Room: Hall


 Keynote Speaker: Francesca Dominici, Harvard University, USA - Room: Auditorio

    Chair: Guadalupe Gómez Melis
    Model Uncertainty and Covariate Selection in Causal Inference

 ISCB Annual General Meeting - Room: Auditorio


Lunch break - Room: Sala Congresos


IS7: Bayesian Methods in Clinical Research - Room: Auditorio

    Chair: Carmen Armero  
    Organised by Carmen Armero, University of Valencia, Spain


IS7-1 Heinz Schmidli, Novartis Pharma AG, Switzerland - Bayesian Evidence Synthesis for Extrapolation in Clinical Research

IS7-2 Peter Müller, University of Texas at Austin, USA - A Population-Finding Design with Covariate-Dependent Random Partitions 

IS7-3 Lisa Hampson, Lancaster University, United Kingdom - Use of Bayesian Approaches for Extrapolating from Adult Efficacy Data to Design and Interpret Confirmatory Trials in Children



 OC35: Complex survival data 2 - Room: Sala Terra 2

    Chair: Hans Van Houwelingen
    OC35-1 (14.30-14.48) Ruth Keogh - Flexible modelling of personalised dynamic prediction curves using landmarking, with a case-study in cystic fibrosis
    OC35-2 (14.49-15.06) Kaspar Rufibach - Joint modelling of progression-free and overall survival
    OC35-3 (15.07-15.24) Mailis Amico - A ROC curve approach for cure status prediction from survival data
    OC35-4 (15.25-15.42) Anna Wolski - Comparison of net survival with non-proportional hazard functions: a test based on restricted net survival time
    OC35-5 (15.43-16.00) Song Yang - Improving the testing of treatment effect in clinical trials with time to event outcomes

 OC36: Statistical methods for precision medicine 2 - Room: Sala Mar 4

    Chair: Tim Friede
    OC36-1 (14.30-14.48) Kukatharmini Tharmaratnam - Point and interval estimation for predicting individual treatment effect based on randomized clinical trial data
    OC36-2 (14.49-15.06) Zhi Zhao - Approaches to incorporate drug-drug similarity in multi-response penalized likelihood methods for predicting drug response based on multi-omics data
    OC36-3 (15.07-15.24) Erik Van Werkhoven - Development of treatment-selection markers for studies with failure-time outcomes
    OC36-4 (15.25-15.42) Antonia Marsden - Evaluating treatment effect modification on the additive scale to investigate predictors of differential treatment response
    OC36-5 (15.43-16.00) Taesung Park - Pathway-based approach to NGS data with multiple phenotypes

 OC37: Design and analysis of clinical trials 5 - Room: Sala Mar 2

    Chair: Sandra Lee
    OC37-1 (14.30-14.48) Yida Chiu - Graphical displays for subgroup analysis in clinical trials
    OC37-2 (14.49-15.06) Lieven Desmet - A correlation test for central statistical monitoring of multicenter clinical trials
    OC37-3 (15.07-15.24) Frank Bretz - Assessing the similarity of dose response and target doses in two non-overlapping populations
    OC37-4 (15.25-15.42) Yonghong Gao - Use of ordinal scale endpoint in therapeutic influenza clinical study
    OC37-5 (15.43-16.00) Zoe Moodie - Correlates of risk and protection of CYD-TDV, the first licensed dengue vaccine in endemic countries

 OC38: Statistical methods in epidemiology 3 - Room: Sala Terra 4

    Chair: Ana Luisa Papoila
    OC38-1 (14.30-14.48) Evangelia Christodoulou - Using indices to estimate the association of >1 exposures with quantitative, binary and time-to event health outcomes 
    OC38-2 (14.49-15.06) Coraline Danieli - Modeling of cumulative effects of time-varying drug exposures on changes in a longitudinal biomarker
    OC38-3 (15.07-15.24) Helene Jacqmin-Gadda - Weighted two-stage calibration for adjustment on unobserved confounders with non-representative validation sample

OC38-4 (15.25-15.42) David Van Klaveren - The calibrated model-based concordance improved assessment of discriminative ability in patient clusters of limited sample size

    OC38-5 (15.43-16.00) Pedro Sa-Couto - A graphical guideline for the selection of reliability and agreement methods for clinical studies

 PC7: Observational studies - Room: Hall

    Chair: Els Goetghebeur
    Click here to see the posters list

Coffee break - Room: Hall


 IS8: Clinical Trial Simulations: the When, Where and What - Room: Auditorio

    Chair: Mouna Akacha
    Organised by Geraldine Rauch, University of Heidelberg, Germany


IS8-1 Frank Konietschke, University of Dallas, USA - Parametric and Nonparametric Bootstrap Methods for General MANOVA

IS8-2 Tim Friede, Georg-August University of Göttingen, Germany (Co-author: Norbert Benda, BfArM, Bonn) - A Framework for Simulations in Clinical Research with Applications in Small Populations and Rare Diseases

IS8-3 Antje Jahn, University of Mainz, Germany - Simulating Recurrent Event Data with a Calendar Time Scale


 OC39: Bayesian methods in clinical research 5 - Room: Sala Mar 2

    Chair: Peter Müller
    OC39-1 (16.30-16.48) Pablo Emilio Verde - The hierarchical meta-regression approach and learning from clinical evidence
    OC39-2 (16.49-17.06) Miguel Caubet Fernández - A Bayesian multivariate latent t-model for assessing the effects of intracranial radiotherapy and corticosteroid therapy on cardiometabolic risk factors in survivors of childhood acute lymphoblastic leukemia
    OC39-3 (17.07-17.24) Despina Vasileiou - Bayesian clinical trial design for rare diseases; prior opinion elicitation for chronic rheumatoid multifocal osteomyelitis
    OC39-4 (17.25-17.42) Christian Röver - Extrapolation in meta-analysis
    OC39-5 (17.43-18.00) Elena Lázaro - Dealing with baseline hazard functions in Bayesian joint models

 OC40: Joint modelling in practice 3 - Room: Sala Mar 4

    Chair: Giota Touloumi
    OC40-1 (16.30-16.48) Anaïs Rouanet - Dynamic predictions from joint models for multiple longitudinal markers correlated to interval-censored competing events
    OC40-2 (16.49-17.06) Sara Baart - Joint models for longitudinal and time-to-event data in a case-cohort design
    OC40-3 (17.07-17.24) Sam Brilleman [StCA winner] - Bayesian joint models for multiple longitudinal biomarkers and a time-to-event outcome: software development and a melanoma case study
    OC40-4 (17.25-17.42) Maria Sudell - Practical methods to pool multi-study joint longitudinal and time to event data
    OC40-5 (17.43-18.00) Roger Marshall - Enhancing regression  nomograms  to provide a graphical representation of disease risk prediction regression models

 OC41: Topics in biostatistics 2 - Room: Sala Terra 4

    Chair: Montse Rué
    OC41-1 (16.30-16.48) Robin Ristl - Simultaneous inference for multiple marginal GEE models with small sample sizes
    OC41-2 (16.49-17.06) Sabine Hoffmann - Elicitation of the knowledge of several experts to derive informative prior distributions on biological parameters in radiation epidemiology
    OC41-3 (17.07-17.24) Javier Rivera - Getting relevant groups of bacteria in microbiome analysis
    OC41-4 (17.25-17.42) María Álvarez Hernández - Alfa coefficient: an alternative measure of categorical agreement among many raters
    OC41-5 (17.43-18.00) Abhik Ghosh [CASc winner] - Robust inference under the beta regression model with application to health care studies

 OC42: Survival analysis 4 - Room: Sala Terra 2

    Chair: Virginie Rondeau
    OC42-1 (16.30-16.48) Adina Najwa Kamarudin - Measuring the effectiveness of diagnostic markers in the presence of measurement error through the use of time-dependent ROC curve methodology
    OC42-2 (16.49-17.06) Steve Su - Flexible parametric accelerated failure model
    OC42-3 (17.07-17.24) Enya Weber - Quantifying the association between progression-free survival and overall survival in cancer trials
    OC42-4 (17.25-17.42) Michel Hof - A probabilistic record linkage model for left truncated time-to-event data with competing risks
    OC42-5 (17.43-18.00) Menglan Pang - Flexible accelerated failure time model for right censored data in survival analysis

 PC8: Biomedical studies 2 - Room: Hall

    Chair: Jeanine Houwing-Duistermaat
    Click here to see the posters list

 ISCB39 Presentation - Room: Auditorio


 Conference Dinner at Hotel Pazo Los Escudos (Beach of Alcabre)


Location: Hotel Pazo Los Escudos, Avda. Atlántida, 106


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